p63 (Squamous , Basal and Myoepithelial Cell Marker) (TP63/1786) , CF647 conjugate , 0.1mg / mL

p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues , including epidermis , cervix , urothelium , breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however , it was not expressed in malignant tumors of the prostate. As a result , p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate , particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC) , with a sensitivity of ~90%. Specificity for lung SqCC , vs. lung adenocarcinoma (LADC) , is approximately 80%. In breast tissue , p63 has been identified in myoepithelial cells of normal ducts._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_