SOX10(SOX10/992) , 1mg / mL

Recognizes a protein of ~55 kDa , identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the Hmg -box domain , which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma , including conventional , spindled , and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes , but not by other lymph node components such as dendritic cells , which usually express S100 protein. Commonly used melanoma markers , such as anti-HMB-45 and anti-Melan-A , are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues , it is expressed in Schwann cells , melanocytes , and myoepithelial cells of salivary , bronchial and mammary glands. SOX-10 expression is also observed in mast cells._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_